Isomer Investigations: Navigating Complex Cannabinoid Science with Nelly Mikhaltsevich

In this episode of Impairment Perspectives, host Joey Jones talks with Nelly Mikhaltsevich, a Forensic Scientist III with the Ventura County Sheriff’s Office Forensic Services Bureau, about the complex and evolving world of cannabinoid testing in forensic toxicology.

Nelly shares her journey from student aide to experienced forensic scientist, reflecting on nearly two decades in the crime lab and her growing expertise in cannabinoid analysis. The conversation explores the scientific challenges of separating and identifying THC isomers, including Delta-8 and Delta-9 THC, and the importance of developing validated LC-MS/MS methods in a post-Farm Bill landscape.

Joey and Nelly also discuss the realities of method validation, courtroom testimony, laboratory problem-solving, and the balance between high-stakes forensic work and family life. This episode offers an inside look at the precision, persistence, and curiosity required to keep forensic toxicology moving forward as drug trends continue to change.